Description

Author: Klingeler, Rüdiger; Sim, Robert B. (Eds.)
ISBN 978-3-642-14801-9 

1st Edition., 2011, XX, 280 p. 38 illus. in color., Hardcover

Summary

This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

Table of Contents

Part I Fundamental: Synthesis of  Multifunctional Nanomaterials and their Potential for Medical Application

1. Physical Properties of Carbon Nanotubes for Therapeutic Application

2.  Carbon Nanotubes in Regenerative Medicine

3. Filling of Carbon Nanotubes with Compounds in Solution or Melted Phase

4.  Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery

Part II Magnetically Functionalised Carbon Nanotubes for Medical Diagnosis and Therapy

5.  Magnetic Nanoparticles for Diagnosis and Medical Therapy

6. Feasibility of Magnetically Functionalised Carbon Nanotubes for Biological Applications: From Fundamental Properties of Individual Nanomagnets to Nanoscaled Heaters and Temperature Sensors

6. Nuclear Magnetic Resonance Spectroscopy and Imaging of Carbon Nanotubes

Part III Interaction with Biological Systems

7. Exploring Carbon Nanotubes and Their Interaction with Cells Using Atomic Force Microscopy

8. Uptake, Intracellular Localization and Biodistribution of  Carbon Nanotubes

9. Recognition of  Carbon Nanotubes by Human Innate Immune System

10. Toxicity and Environmental Impact of Carbon Nanotubes 

Part IV Towards Targeted Chemotherapy and Gene Delivery

11. Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment

12. Carbon Nanotubes Filled with Carboplatin:  Towards Supported Delivery of Chemotherapeutic Agents

13. Functionalized Carbon Nanotubes for Gene Biodeloivery